Proteomics

We are a close-knit, driven, and patient-focused team of drug discovery and precision oncology experts bringing a new dimension to precision oncology. We have discovered new ways to selectively inhibit oncogenic drivers with small molecules that conditionally modulate proteins in their functional state. Our conditional inhibitors are unlocking critical and elusive cancer targets including TEAD and CDK2.

We are looking for an experienced Senior Scientist I/II with hands-on expertise in proteomics and strong desire for executing on strategies aimed to identify and characterize novel ways to drug difficult targets working closely with other Cedilla scientists. As a Senior Scientist I/II you will join our growing team as a key contributor to Cedilla’s strategy to “putting proteins in context”. You will develop and use MS proteomics methods to explore the diverse proteoform pool and interactome for selected proteins of interest, in relevant biological context, to identify opportunities for therapeutic intervention.

We view you as a thoughtful scientific leader in the company, whose contributions will be critical to the success of our endeavor. Those contributions include:

Operate, optimize, and maintain our LC-MS platforms
Establish robust proteomic workflows to conduct experiments that investigate the effect of the cellular context on protein function.
Perform and drive analysis and interpretation of complex quantitative proteomic data.
Identify and integrate relevant internal and external data and knowledge resources to enable data mining in biological context.
Identify and characterize protein-ligand and protein-protein interactions (PLIs and PPIs) and post-translational modifications (PTMs) using state-of-the-art methods.
Participate and collaborate on multi-disciplinary teams to answer key scientific questions that support the selection and enablement of high value drug targets, and to characterize the mechanism of action (MoA) and in-cell engagement of small molecules.
Manage external partners to complement in-house capabilities.
Experience with designing, implementing and analyzing HDX experiments and/or with other structural proteomic experiments (including experimental design, data collection, interpretation, and presentation) will give you immediate impact.

Some of the highlights of your background are:

Ph.D. with 3+ years of relevant academia or industry experience or MS with 7+ years of industry experience
Expertise in sample preparation (e.g. fractionation and labeling), protein isolation (e.g. enrichment), operating state-of-the-art LC-MS systems and processing, analyzing and interpreting proteomics data.
Proven track record in the implementation and optimization of quantitative high-resolution mass spectrometry (qHRMS) workflows applied towards the study of PLIs, PPIs and PTMs.
Prior experience in Top- or Middle-Down and targeted proteomics, are highly desirable.
Creative and independent scientific thinking to solve complex technical and scientific problems.
Capable of integrating information generated from multiple sources to shape and strengthen experimental design and research hypotheses.
Highly self-motivated, with excellent attention to detail and strong organizational and communication skills.
Ability to work independently, yet team-oriented, capable of mentoring junior team members, and building strong relationships with peers, customers and partners/collaborators.

*To apply, please submit your resume to careers@cedillatx.com

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Research Associate I/II, Biology

We are looking for a driven, collaborative Research Associate to join our growing Biology team. The Research Associate will be responsible for developing innovative cellular assays to enable cancer drug discovery and validating potential drug targets using the latest genetic technology. A successful candidate will be a team player with intellectual curiosity who seeks a scientifically rigorous environment for their career development in drug discovery.

We view you as a key contributor whose contributions will be critical to our success. Your job responsibilities will include:

Design, develop and execute cancer biology experiments focused on the identification and validation of new drug targets
Design, develop, optimize, and execute cellular assays to support drug discovery programs and characterize mechanism of action for drug candidates
Proactively review literature to bring in newest scientific findings, ideas, and methods/technologies for discovery research
Interpret, summarize, and present research findings in internal scientific meetings
Actively participate in and collaborate with multidisciplinary drug discovery teams
Support the management of ongoing work at external CROs

Some of the key requirements in your background are:

BS or MS in Cell & Molecular Biology, Genetics or related discipline
1+ years of Cell biology skills working with established cell lines
Experience in cancer biology and drug discovery preferred
Expertise with all or some of the following: mammalian cell culture, genetic engineering (siRNA, shRNA, sgRNA, CRISPR knock-in), transfections and transductions, cell-based assays (proliferation, apoptosis, viability, reporter), Western blotting, ELISA, cellular immunostaining, flow cytometry/cell sorting
Familiarity with molecular biology and cloning
Outstanding interpersonal skills, thriving in a “teach and learn” environment
Collaborative, flexible, and a “go-getter” mentality
Excellent written and verbal communication skills, as well as strong organizational and problem-solving abilities

To apply, please submit your resume to careers@cedillatx.com

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Associate Director / Director, Preclinical Project Management

You are a drug discovery scientist with experience leading program management for late lead optimization through IND-filing. As the Preclinical Project Manager you will work with preclinical project teams and scientific leadership, helping to develop, drive and coordinate project strategy and execution. Ideally with a scientific drug discovery background, you would draw on successful project management experience, obtained in a biotech or pharma setting. Intellectual and scientific curiosity, flexibility, personal motivation and drive are key attributes for all members of our team.

We view you as a key leader/scientist in the company, whose contributions will be critical to the success of our endeavor. Your role would include:

Leads program management activities for late lead optimization through development candidate selection, preclinical development and IND-filing.
Supports the project leaders and the project team in the development of the program strategy for selection of the development candidate and progression into clinical development, by planning and tracking activities in late lead optimization, pre-clinical development, through IND filing.
In support of project leaders, create integrated development plans, develop and analyze program strategies/costs/risks and revise plans accordingly. Identify, track, and support resolution efforts for all program-related issues.
Collaborate with Clinical Operations, Clinical Development and Regulatory Affairs around IND preparation to ensure team-based approach with efficient workflow.
Facilitate resolution of conflicts between functional groups while maintaining objectivity
Builds team spirit and positive team environment.
Mentor, supervise and encourage development of scientists working in pre-clinical development.

Some of the highlights of your background are:

10+ years of relevant biotech or pharmaceutical industry experience.
3+ years in a program management role. Hands on experience in leading program management activities for programs in preclinical development.
Strong scientific background in Biology, Chemistry, or other area of drug discovery or clinical development. Postgraduate degree in the sciences a plus.
Oncology experience strongly preferred.
Able to handle complexity and ambiguity as well as be able to prioritize effectively
Demonstrated ability to lead by influence, cross-functionally.
Must have the ability to motivate others, prioritize multiple tasks, and maintain positive interpersonal skills.
Must be able to clearly communicate complex program information in formal and informal settings.
Good conflict resolution and problem-solving skills are a must.
Experience setting and maintaining budgets.
Knowledge of project management tools (GANTs, Excel, etc.).

*To apply, please submit your resume to careers@cedillatx.com

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