Computational Biologist

Computational Biologist

We are a team of seasoned drug discoverers and developers on a mission to bring forward a new generation of targeted therapies for the treatment of cancer and other diseases caused by protein dysregulation. The company employs a target-centric approach, focusing on scientifically validated drivers of disease that have eluded conventional therapeutic modalities. Cedilla identifies functionally relevant proteoforms, or protein states, creating novel opportunities for therapeutic intervention.

You are an innovative and enthusiastic computational biologist eager to work with researchers across scientific disciplines and with the computational/informatics group. You will be an important part of drug discovery teams and help guide omics level data analysis to advance scientific understanding and bring therapies to patients in need.

We view you as a member of a dynamic team of multidisciplinary scientists who can work with teams both internal and external. Your role would include:

  • Analyzing proprietary omics datasets to advance understanding of drug targets and compound inhibition for oncology drug programs
  • Devising new models and algorithms using omics and genetic perturbation datasets for target selection, biomarker identification, and indication selection
  • Exploring and developing novel data visualization tools
  • Collaborating with lab scientists as a project team member to help guide downstream data analysis
  • Communicating and presenting results to biologists, computational biologists, and other scientists

Some of the highlights of your background are:

  • Ph.D. or equivalent in a quantitative discipline (such as computer science, bioinformatics, math, physics, or engineering) with biology experience, or in biology with a strong quantitative background. Industry experience is a plus
  • Experience with statistical and machine learning methods applied to biology and drug discovery
  • Experience working with common “omics” datasets, such as transcriptomic, genomic, and proteomic data
  • Proficient programming skills and computational analysis background. Experience with R and/or Python is highly desirable
  • Ability to formulate and test hypotheses by designing and implementing computational approaches independently with minimal supervision
  • Ability to effectively interpret and communicate conclusions from complex data is essential

*To apply, please submit your resume to careers@cedillatx.com

Manager/Sr. Manager, People Operations

Manager/Sr. Manager, People Operations

We are a team of seasoned drug discoverers and developers on a mission to bring forward a new generation of targeted therapies for the treatment of cancer and other diseases caused by protein dysregulation. The company employs a target-centric approach, focusing on scientifically validated drivers of disease that have eluded conventional therapeutic modalities. Cedilla identifies functionally relevant proteoforms, or protein states, creating novel opportunities for therapeutic intervention.

You are a mission-driven leader who is passionate about elevating Cedilla’s “Teach and Learn” culture by designing and building initiatives supporting career growth, employee development and connectedness between members of our growing team.

We view you as a naturally curious and thoughtful collaborator who can help raise our people and culture game. Your role will include:

  • Partnering with team members to develop and deploy programs, technology and data-driven efforts promoting high-performance, engagement and connectedness across the organization
  • Collaborating with managers to understand and pre-empt needs related to employee engagement, talent development and employee relations
  • Providing leadership and guidance in facilitating employee relations matters in a positive and proactive manner to ensure appropriate resolution and follow through
  • Championing a diverse, equitable and inclusive workplace via employee development efforts, partnerships with non-profits, educational offerings and by evolving practices and policies to support DEI initiatives
  • Partnering with leadership to develop a talent branding strategy and execute plans to convey Cedilla’s culture to attract, engage and interact with prospective candidates and talent communities
  • Managing employee benefit plans and partnering with the Head of People & Culture to assess needs and implement new plans consistent with competitive trends

Some of the highlights of your background are:

  • You enjoy balancing the strategic with the operational, and rolling up your sleeves
  • Collaborating is your default when it comes to problem solving and creative exploration
  • You prioritize relationships, and are able to earn influence by building trust and credibility with your colleagues
  • You know what good looks like when it comes to program design and delivery, and you have an eye for continuous improvement
  • You are comfortable starting the day with a clear plan and changing it after your first cup of coffee
  • A Bachelor’s or Master’s degree is preferred, but not required…and you will probably need 7+ years of experience to perform well in this role

*To apply, please submit your resume to careers@cedillatx.com

Associate Director / Director, Preclinical Project Management

Associate Director / Director, Preclinical Project Management

We are a team of seasoned drug discoverers and developers on a mission to bring forward a new generation of targeted therapies for the treatment of cancer and other diseases caused by protein dysregulation. The company employs a target-centric approach, focusing on scientifically validated drivers of disease that have eluded conventional therapeutic modalities. Cedilla identifies functionally relevant proteoforms, or protein states, creating novel opportunities for therapeutic intervention.

You are a drug discovery scientist with experience leading program management for late lead optimization through IND-filing. As the Preclinical Project Manager you will work with preclinical project teams and scientific leadership, helping to develop, drive and coordinate project strategy and execution. Ideally with a scientific drug discovery background, you would draw on successful project management experience, obtained in a biotech or pharma setting. Intellectual and scientific curiosity, flexibility, personal motivation and drive are key attributes for all members of our team.

We view you as a key leader/scientist in the company, whose contributions will be critical to the success of our endeavor. Your role would include:

  • Leads program management activities for late lead optimization through development candidate selection, preclinical development and IND-filing.
  • Supports the project leaders and the project team in the development of the program strategy for selection of the development candidate and progression into clinical development, by planning and tracking activities in late lead optimization, pre-clinical development, through IND filing.
  • In support of project leaders, create integrated development plans, develop and analyze program strategies/costs/risks and revise plans accordingly. Identify, track, and support resolution efforts for all program-related issues.
  • Collaborate with Clinical Operations, Clinical Development and Regulatory Affairs around IND preparation to ensure team-based approach with efficient workflow.
  • Facilitate resolution of conflicts between functional groups while maintaining objectivity
  • Builds team spirit and positive team environment.
  • Mentor, supervise and encourage development of scientists working in pre-clinical development.

Some of the highlights of your background are:

  • 10+ years of relevant biotech or pharmaceutical industry experience.
  • 3+ years in a program management role. Hands on experience in leading program management activities for programs in preclinical development.
  • Strong scientific background in Biology, Chemistry, or other area of drug discovery or clinical development. Postgraduate degree in the sciences a plus.
  • Oncology experience strongly preferred.
  • Able to handle complexity and ambiguity as well as be able to prioritize effectively
  • Demonstrated ability to lead by influence, cross-functionally.
  • Must have the ability to motivate others, prioritize multiple tasks, and maintain positive interpersonal skills.
  • Must be able to clearly communicate complex program information in formal and informal settings.
  • Good conflict resolution and problem-solving skills are a must.
  • Experience setting and maintaining budgets.
  • Knowledge of project management tools (GANTs, Excel, etc.).

*To apply, please submit your resume to careers@cedillatx.com

Senior Scientist, Chemical Biology

Senior Scientist, Chemical Biology

We are a team of seasoned drug discoverers and developers on a mission to bring forward a new generation of targeted therapies for the treatment of cancer and other diseases caused by protein dysregulation. The company employs a target-centric approach, focusing on scientifically validated drivers of disease that have eluded conventional therapeutic modalities. Cedilla identifies functionally relevant proteoforms, or protein states, creating novel opportunities for therapeutic intervention.

You are an experienced scientist with hands-on expertise in chemical biology and strong desire for executing on strategies aimed to identify and characterize novel ways to drug difficult targets working closely with other Cedilla scientists. As a Chemical Biology Senior Scientist you will join our growing team as a key contributor to Cedilla’s strategy to “putting proteins in context”. You will develop and use chemical biology probes and workflows to explore the diverse proteoform pool and interactome for selected proteins of interest, in relevant biological context, to identify opportunities for therapeutic intervention.

We view you as a thoughtful scientific leader in the company, whose contributions will be critical to the success of our endeavor. Those contributions include:

  • Designing chemical biology strategies, conducting experiments and interpreting complex data to investigate the effect of the cellular context on protein function.
  • Identifying and characterizing protein-ligand and protein-protein interactions (PLIs and PPIs) and post-translational modifications (PTMs) using state-of-the-art methods.
  • Participating on multi-disciplinary teams, collaborating with colleagues in biochemistry, biophysics and cell biology to answer key scientific questions that support the selection and enablement of high value drug targets, and to characterize the mechanism of action (MoA) and in-cell engagement of small molecules. 
  • Working closely with external partners to complement in-house capabilities.

Some of the highlights of your background are:

  • Expertise in bio-compatible and biorthogonal synthetic chemistry methods and principles for structure-activity relationship (SAR) optimization applied towards the design and selection of chemical biology probes for protein labeling, residue mapping and activity-based proteomics.
  • Proven track record in the implementation of diverse chemical biology and chemo-proteomics workflows and experiments applied to study PLIs and PPIs. Hands-on experience using proximity-based labeling (such as BioID or APEX), chemically-induced proximity (CIP) and activity-based proteomic profiling (ABPP) methods are highly desirable.
  • General understanding of quantitative high-resolution MS workflows with hands-on experience in sample preparation are preferred.
  • Creative and independent scientific thinking to solve complex technical and scientific problems. Capable of integrating information generated from multiple sources to shape and strengthen experimental design and research hypotheses.
  • Highly self-motivated, with excellent attention to detail and strong organizational and communication skills. Ability to work independently, yet team-oriented and capable of mentoring junior team members, building strong relationships with peers, customers and partners/collaborators.
  • Ph.D. or equivalent with 6+ years of industry applied experience, with a focus on chemical biology.

*To apply, please submit your resume to careers@cedillatx.com

Senior Scientist, Proteomics

Senior Scientist, Proteomics

We are a team of seasoned drug discoverers and developers on a mission to bring forward a new generation of targeted therapies for the treatment of cancer and other diseases caused by protein dysregulation. The company employs a target-centric approach, focusing on scientifically validated drivers of disease that have eluded conventional therapeutic modalities. Cedilla identifies functionally relevant proteoforms, or protein states, creating novel opportunities for therapeutic intervention.

You are an experienced scientist with hands-on expertise in proteomics and strong desire for executing on strategies aimed to identify and characterize novel ways to drug difficult targets working closely with other Cedilla scientists. As a Proteomics Senior Scientist you will join our growing team as a key contributor to Cedilla’s strategy to “putting proteins in context”. You will develop and use MS proteomics methods to explore the diverse proteoform pool and interactome for selected proteins of interest, in relevant biological context, to identify opportunities for therapeutic intervention.

We view you as a thoughtful scientific leader in the company, whose contributions will be critical to the success of our endeavor. Those contributions include:

  • Operating and maintaining our LC-MS platforms and establishing robust proteomic workflows to conduct experiments that investigate the effect of the cellular context on protein function.
  • Performing analysis and interpretation of complex quantitative proteomic data. Identifying and integrating relevant internal and external data and knowledge resources to enable data mining in biological context.
  • Identifying and characterizing protein-ligand and protein-protein interactions (PLIs and PPIs) and post-translational modifications (PTMs) using state-of-the-art methods.
  • Participating on multi-disciplinary teams, collaborating with colleagues in biochemistry, biophysics and cell biology to answer key scientific questions that support the selection and enablement of high value drug targets, and to characterize the mechanism of action (MoA) and in-cell engagement of small molecules. 
  • Working closely with external partners to complement in-house capabilities.

Some of the highlights of your background are:

  • Ph.D. or equivalent with 6+ years of industry applied experience, with a focus on proteomics.
  • Expertise in sample preparation (e.g. fractionation and labeling), protein isolation (e.g. enrichment), operating state-of-the-art LC-MS systems and processing, analyzing and interpreting proteomics data.
  • Proven track record in the implementation and optimization of quantitative high-resolution mass spectrometry (qHRMS) workflows applied towards the study of PLIs, PPIs and PTMs.
  • Prior experience in Top- or Middle-Down and targeted proteomics, are highly desirable.
  • Creative and independent scientific thinking to solve complex technical and scientific problems. Capable of integrating information generated from multiple sources to shape and strengthen experimental design and research hypotheses.
  • Highly self-motivated, with excellent attention to detail and strong organizational and communication skills. Ability to work independently, yet team-oriented and capable of mentoring junior team members, building strong relationships with peers, customers and partners/collaborators.  

*To apply, please submit your resume to careers@cedillatx.com

Associate Director / Director, Computational Chemistry

Associate Director / Director, Computational Chemistry

Job description

About Cedilla Therapeutics:

Cedilla is a private biotechnology company developing targeted small molecule medicines for the treatment of cancer and other diseases caused by protein dysregulation. The company employs a target-centric approach, focusing on scientifically validated drivers of disease that have eluded conventional therapeutic modalities. Cedilla identifies functionally relevant proteoforms, or protein states, creating novel opportunities for therapeutic intervention. For more information, visit www.cedillatx.com.

Position Overview:

We are looking for a scientist with broad expertise in computational chemistry, chemical informatics, and small molecule drug discovery.  You will help move our programs from target selection and hit finding through clinical candidate selection.  You will also be responsible for developing and implementing internal and commercial tools to enable Cedilla’s platform and programs.  Intellectual and scientific curiosity, flexibility, personal motivation and drive are key attributes for all members of our team.

Job Responsibilities:

  • Define appropriate modeling software needs to support all medicinal chemistry and cheminformatics efforts, in collaboration with IT/Research Informatics colleagues.
  • Work with project teams to generate structural hypotheses for new analog design, as part of our Design/Make/Test/Analyze cycles.
  • Execute both structure-based and ligand-based work-flows, including development of pharmacophore and QSAR models, ligand docking, virtual screening, protein-protein interaction, MD simulation and energy perturbation calculations.
  • Develop methodologies to inform on protein conformational space accessibility, including free energy methods and energetic analysis.
  • Develop custom tools to enable data analysis, sharing and visualization.
  • Provide scientific leadership within a multi-disciplinary drug discovery team, particularly providing guidance to internal and external chemistry teams for new target designs.

Job Requirements:

  • Ph.D. in computational chemistry, chemical informatics, physical organic chemistry, biophysics or related field.
  • 8 years of relevant pharmaceutical industry experience on multiple successful small molecule programs.
  • Solid understanding of chemometrics, which includes QSAR methodologies, pharmacophore development, 2D and 3D similarity, data mining and visualization, protein modeling, conformational analysis, molecular docking, library analysis and design.
  • Ability to work across various disciplines involved in small molecule drug discovery, including working with colleagues in Computational Biology and Computational Proteomics.
  • Expertise in medicinal chemistry and basic knowledge of synthetic organic chemistry.
  • Ability to work independently within a collaborative environment while demonstrating leadership, creativity and adaptability in your scientific work.
  • Strong analytical and problem-solving skills and scientific creativity are essential.
  • Strong scientific programming skills (Perl, Python, R, Linux) and expertise with pipelining tools (Knime, Pipeline Pilot)

Cedilla is an equal opportunity employer. We recruit, employ, train, compensate, and promote without regard to race, religion, creed, national origin, age, gender, sexual orientation, sexual identity, marital status, military or veteran status, disability, genetic information, or any other category protected by applicable federal, state or local law.

Cedilla does not accept unsolicited agency resumes. Staffing agencies should not send resumes to our HR team or to any Cedilla employees. Cedilla is not responsible for any fees related to unsolicited resumes from staffing agencies.

*To apply, please submit your resume to careers@cedillatx.com