Cedilla Therapeutics Appoints Chris Bowden, M.D. to its Board of Directors

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Cedilla Therapeutics Appoints Chris Bowden, M.D. to its Board of Directors

CAMBRIDGE, Mass., April 21, 2021 – Cedilla Therapeutics, a venture-backed preclinical biotechnology company developing novel small molecules for cancer and other diseases, today announced the appointment of Chris Bowden, M.D., to its Board of Directors.

“Chris brings tremendous industry experience to Cedilla, with more than two decades of oncology drug development leadership, having successfully brought multiple novel medicines to market,” said Alexandra Glucksmann, Ph.D., President and Chief Executive Officer of Cedilla Therapeutics. “His insights will be particularly valuable as we prepare to nominate our first two precision therapeutic oncology drug candidates. We look forward to his many contributions as we advance our lead programs and work to build a broad portfolio of small molecule medicines that can redirect the course of disease and deliver profound benefit to patients.”

Dr. Bowden joined Agios as Chief Medical Officer in May 2014, leading clinical development activities that resulted in the TIBSOVO® approvals for IDH1 mutation positive acute myeloid leukemia in the U.S. Prior to joining Agios, Dr. Bowden was vice president product development oncology, franchise lead (Signaling Group) at Genentech, Inc., a member of the Roche Group. During Dr. Bowden’s eight years at Genentech, he was responsible for the successful development of a number of novel targeted oncology medicines, including Zelboraf™ for patients with BRAF V600E positive melanoma and Tarceva™ for patients with EGFr activating mutation positive, non-small cell lung cancer. From 2003 to 2006, Dr. Bowden was the executive director for EMEA (Europe, Middle East, Africa) regions for Bristol-Myers Squibb. In this role, he led medical affairs strategies for cancer, immunology and pain medicines. Earlier, Dr. Bowden held positions of increasing responsibility in oncology clinical development at Pharmacia Corporation and Janssen Pharmaceutical, Inc. Prior to his industry experience, Dr. Bowden was on the oncology faculty at the University of Virginia Health Science Center where he participated in numerous industry and cooperative group trials. Dr. Bowden received his medical degree from Hahnemann University School of Medicine in Philadelphia followed by internal medicine training at Roger Williams Medical Center and the Providence VA Medical Center, Rhode Island. He completed his medical oncology fellowship at the National Cancer Institute Medicine Branch. Dr. Bowden is board certified in internal medicine and medical oncology, and he serves on the board of directors at Ziopharm Oncology Inc.

“This is an exciting time to join Cedilla’s Board of Directors,” said Dr. Bowden. “Cedilla’s unique approach to addressing undruggable targets, coupled with the team’s deep drug development expertise, has the potential to bring much needed therapies to patients. I look forward to working with the board and the management team to advance the next generation of targeted molecular therapeutics, with the goal of enabling even greater reach, precision and impact.”

About Cedilla Therapeutics

Cedilla Therapeutics is a private biotechnology company developing targeted novel small molecule therapeutics directed to unrecognized allosteric binding sites and uncovering novel ways to access key disease drivers. The company employs a target-centric approach and integrates a multidisciplinary set of tools to design novel drug discovery screens that recapitulate the relevant functional state of validated disease drivers that have, to date, eluded conventional therapeutic modalities. For more information, please visit www.cedillatx.com or follow us on LinkedIn.

Investor Contact:

Hannah Deresiewicz
Stern Investor Relations, Inc.
hannah.deresiewicz@sternir.com

Cedilla Therapeutics Announces Appointment of Véronique Riethuisen as Chief Business Officer and Head of Finance

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Cedilla Therapeutics Announces Appointment of Véronique Riethuisen as Chief Business Officer and Head of Finance

CAMBRIDGE, Mass., April 5, 2021 – Cedilla Therapeutics, a venture-backed preclinical biotechnology company developing novel small molecules for cancer and other diseases, today announced the appointment of Véronique Riethuisen as Chief Business Officer and Head of Finance. In this newly created role, Ms. Riethuisen will oversee corporate development, finance and strategic planning and serve as treasurer and company secretary.

“We are thrilled to welcome Véronique to Cedilla. She has an impressive track record shaping and building early and late-stage portfolios for leading biopharmaceutical companies,” said Alexandra Glucksmann, Ph.D., President and Chief Executive Officer of Cedilla Therapeutics. “Véronique’s substantial leadership experience, coupled with her background in corporate and business development, will be instrumental in growing Cedilla. We look forward to her contributions as we execute on our vision of leveraging our novel small molecule drug discovery approach to address the needs of patients with cancer and other diseases.”

“I am honored to join the Cedilla team. Cedilla has developed a novel approach to addressing undruggable targets for the treatment of cancers and diseases caused by protein dysregulation,” said Ms. Riethuisen. “I look forward to working together with my new colleagues to progress a growing portfolio of promising medicines for the benefit of patients.”

Ms. Riethuisen brings over 25 years of experience in global business development, M&A and alliance management leadership to Cedilla. Most recently, Ms. Riethuisen served as Senior Vice President, Global Business Development and Strategic Alliance Management at Ipsen where she helped build Ipsen’s rare disease franchise by acquiring and licensing multiple innovative assets for the treatment of fibrodysplasia ossificans progressiva. She also negotiated Ipsen’s global agreement with Debiopharm for Decapeptyl®, an achievement recognized with the 2020 Award for “Long-Established Alliance” from the Association of Strategic Alliance Professionals. Prior to Ipsen, Ms. Riethuisen was Vice President, Head of Global Transactions at Takeda where she led a team that, in just one year, successfully landed over 20 deals transforming the company’s gastrointestinal and regenerative medicine portfolios. Earlier, Ms. Riethuisen held various business development, M&A and alliance management roles of increasing responsibility at Pfizer, Teva, Bristol Myers Squibb and Monsanto.  Ms. Riethuisen currently serves as an Executive Coach for the MassNextGen program mentoring first-time female chief executive officers, and she teaches a Business Development Fundamentals course annually in conjunction with the BIO Annual Conference. Ms. Riethuisen holds a bachelor and master’s degree in Applied Economics from the University of Brussels (ULB), Belgium.

About Cedilla Therapeutics

Cedilla Therapeutics is a private biotechnology company developing targeted novel small molecule therapeutics directed to unrecognized allosteric binding sites and uncovering novel ways to access key disease drivers. The company employs a target-centric approach and integrates a multidisciplinary set of tools to design novel drug discovery screens that recapitulate the relevant functional state of validated disease drivers that have, to date, eluded conventional therapeutic modalities. For more information, please visit www.cedillatx.com or follow us on LinkedIn.

Investor Contact:

Hannah Deresiewicz
Stern Investor Relations, Inc.
hannah.deresiewicz@sternir.com
212-362-120

Cedilla and HitGen Announce Research Collaboration Focused on DNA-Encoded Library Based Drug Discovery

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Cedilla and HitGen Announce Research Collaboration Focused on DNA-Encoded Library Based Drug Discovery

CHENGDU, China– Shanghai Stock Exchange listed company HitGen Inc. (“HitGen”) today announced that it has entered into a research collaboration agreement with Cedilla Therapeutics, Inc. (“Cedilla”), a private biotechnology company developing targeted small molecules for the treatment of cancer and other diseases caused by protein dysregulation. The companies will conduct joint research to identify and develop drug candidates directed to a validated, high-value target in oncology that has remained beyond the reach of previous efforts.

HitGen is a world leading biotech company in DNA encoded library-screening, a high throughput compound screening technology, where more than 100,000 times larger libraries can be used than in traditional drug discovery. The platform thus enables faster identification of innovative drug candidates with improved target specificity and enhanced drug-like characteristics.

Pursuant to the terms of the collaboration agreement, HitGen has successfully applied its DEL technology and discovered program compounds that met certain criteria, and Cedilla has received an exclusive license to these compounds as well as associated IP for further development and commercialization.  HitGen will be eligible for milestone payments and sublicensing income from Cedilla as the project progresses, in addition to research payments and upfront license fee.

“HitGen is a perfect partner for us in this program, with their cutting-edge DEL platform for screening. Their technology is well established and is now widely used by leading global pharmaceutical and biotech companies,” said Dr. Alexandra Glucksmann, President and CEO of Cedilla. “With HitGen’s support, we are able to accelerate our ongoing efforts to pursue a breadth of high-value oncology targets that have eluded conventional therapeutic modalities. We are very pleased with the program compounds discovered by HitGen to date, are excited to advance these programs forward as we pursue our mission of delivering profound benefit to patients in areas of high unmet need.”

“We are delighted to enter this collaboration with Cedilla, and believe their unique approach to identifying functionally-relevant proteoforms represents a powerful advance in how we think about treating diseases caused by protein dysregulation,” said Dr. Jin Li, Chairman of the Board and Chief Executive Officer of HitGen. “We believe the collaboration will reinforce the role and reputation of HitGen’s platform in the rapidly developing field of DEL and further demonstrates the power of our DEL platform to discover novel small molecules against a variety of targets. We are working closely with Cedilla scientists and have seen early success towards generating new small-molecule lead compounds for their research programs to help bring transformative medicines to patients.”

About Cedilla Therapeutics, Inc.

Cedilla is a private biotechnology company developing targeted small molecule medicines for the treatment of cancer and other diseases caused by protein dysregulation. The company employs a target-centric approach, focusing on scientifically-validated drivers of disease that have eluded conventional therapeutic modalities. Cedilla identifies functionally-relevant proteoforms, or protein states, creating novel opportunities for therapeutic intervention. For more information, visit www.cedillatx.com.

About HitGen Inc.

HitGen is a rapidly growing biotech company with headquarter and main research facility based in Chengdu, China and with a subsidiary in the USA. HitGen has established a platform for small molecule drug discovery research centered on the design, synthesis and screening of DNA encoded chemical libraries (DELs). HitGen’s DELs contain over 400 billion novel, diverse, drug-like small molecule and macrocyclic compounds. These compounds are members of DELs synthesized from many hundreds of distinct chemical scaffolds, designed with tractable chemistry, and yielded proven results for the discovery of small molecule leads against precedented and unprecedented classes of biological targets. HitGen is collaborating with pharmaceutical, biotech, and chemical companies, foundations and research institutes in North America, Europe, Asia and Africa to discover and develop approaches for novel medicines and other solutions.

For more information, please call:
+86-28-85197385
or visit:
www.hitgen.com

For business development: 
bd@hitgen.com

For investor inquiries: 
investors@hitgen.com

For media inquiries: 
media@hitgen.com

Investor Contact (Cedilla):

Hannah Deresiewicz
Stern Investor Relations, Inc.
hannah.deresiewicz@sternir.com
212-362-1200

Cedilla Therapeutics Announces $57.6 Million Series B Financing

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Cedilla Therapeutics Announces $57.6 Million Series B Financing

Financing Co-Led by Leading Public Healthcare Funds, Casdin Capital and Boxer Capital of Tavistock Group

CAMBRIDGE, Mass., October 13, 2020 – Cedilla Therapeutics, a private biotechnology company developing targeted small molecules for the treatment of cancer and other diseases caused by protein dysregulation, today announced the closing of a $57.6 million Series B financing. The financing was co-led by Casdin Capital and Boxer Capital of Tavistock Group and included new investors Eli Lilly and Company and Schroder Adveq, as well as other undisclosed institutional investors, along with existing investor Third Rock Ventures. In connection with the financing, Eli Casdin, Chief Investment Officer and Founder of Casdin Capital, and Dominik Naczynski, Senior Vice President at Boxer Capital, will join the Company’s Board of Directors.

“Cedilla was founded on the understanding that therapeutic targets exist in multiple proteoforms, or protein states, which can be evaluated for functional relevance and exploited to create novel opportunities for intervention, even where conventional approaches have failed,” said Alexandra Glucksmann, Ph.D., Cedilla’s president and chief executive officer. “Over the past two years, we have honed our integrated approach and we are now prepared to advance target-specific efforts toward the clinic. We appreciate the support of our new and existing investors, which will enable us to name our first two development candidates, expand our discovery-stage research and work toward our goal of delivering novel small molecules that can redirect the course of disease and deliver profound benefit to patients.”

Cedilla identifies previously unexploited proteoforms of high-value targets. While prior attempts to drug these targets have focused only on their canonical states, Cedilla has discovered the means to affect function or stability by engaging pivotal, post-translationally modified states. Cedilla’s product candidates are designed with mechanisms best fit to modulate these functionally-relevant proteoforms, which may include protein inhibition or degradation. Proceeds from this financing will support ongoing efforts to build a broad portfolio of small molecule medicines, including the identification and preclinical development of Cedilla’s first two product candidates.

“Cedilla is establishing an entirely new approach to drug development, based on a deep understanding of proteomics and a unique ability to identify and modulate functionally-relevant proteoforms of high-value targets,” said Eli Casdin, Chief Investment Officer and Founder of Casdin Capital. “It is a big idea with powerful potential and we are excited to partner with the management team to accelerate the next stage of the company’s growth.”

About Cedilla Therapeutics

Cedilla Therapeutics is a private biotechnology company developing targeted small molecule medicines for the treatment of cancer and other diseases caused by protein dysregulation. The company employs a target-centric approach, focusing on scientifically-validated drivers of disease that have eluded conventional therapeutic modalities.  Cedilla identifies functionally-relevant proteoforms, or protein states, creating novel opportunities for therapeutic intervention.

For more information, please visit www.cedillatx.com or follow us on LinkedIn.

Investor Contact:

Hannah Deresiewicz
Stern Investor Relations, Inc.
hannah.deresiewicz@sternir.com
212-362-1200

Cedilla Therapeutics Appoints Justin Birtz as Vice President, People and Culture

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Cedilla Therapeutics Appoints Justin Birtz as Vice President, People and Culture

CAMBRIDGE, Mass. Oct. 23, 2019 — Cedilla Therapeutics, a preclinical biotech company harnessing protein stability to create the next generation of targeted cancer therapies,today announced the appointment of Justin Birtz as vice president, people and culture. Mr. Birtz brings to the role nearly two decades of talent and organizational development experience.

Mr. Birtz joins Cedilla from BitSight, where he was director, people operations. There, Mr. Birtz designed and developed the company’s first programs in leadership development, new leader onboarding and performance management with the goal of evolving company culture and inspiring new ways of thinking. In his role at Cedilla, Mr. Birtz will align Cedilla’s mission, values and talent strategy to connect, engage and develop remarkable professionals who share a passion for improving the lives of patients.

“Justin will be instrumental in building internal initiatives to assure that each individual within our deeply skilled network can impact the company and its success,” said Sandra Glucksmann, Ph.D., chief executive officer of Cedilla. “I’m delighted to welcome him to the team.”

Prior to BitSight, Mr. Birtz was director, HR business partnership and director, learning and organizational development at iRobot. Previously, Mr. Birtz spearheaded growth initiatives as an HR manager at Imprivata, Teladoc and Symbotic. He holds a master’s degree in human resource management from Framingham State University and a bachelor’s degree in management from Isenberg School of Management, University of Massachusetts at Amherst.

“Cedilla is composed of many talented scientists and leaders,” commented Mr. Birtz. “I am excited to lead the efforts to develop this team, capitalizing on a diverse workforce that shares a passion for helping patients.”

Added Dr. Glucksmann: “Our company recognizes the importance of meeting goals together. We celebrate the achievements that move us one step closer to building an industry-leading platform and deep pipeline of targets to treat diseases caused by protein dysfunction.”

About Cedilla Therapeutics

Cedilla Therapeutics is a biotechnology company dedicated to improving the lives of patients by delivering the next generation of targeted cancer therapies that precisely modulate critical disease-driving proteins. The company employs an integrated approach that uses small molecules to assess multiple mechanisms for restoring protein homeostasis. Cedilla harnesses the mechanisms most likely to succeed for individual, high-value oncology targets. While adding to industry knowledge of protein degradation, Cedilla is building a powerful, industry-leading platform and broad pipeline of therapeutics. Cedilla was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

For more information, please visit www.cedillatx.com or follow us on LinkedIn.

Media Contact:

Molly Rusert
Ten Bridge Communications
molly@tenbridgecommunications.com
612-232-2084

Cedilla Therapeutics Appoints Delphine Collin, Ph.D., as Vice President, Biomolecular Sciences

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Cedilla Therapeutics Appoints Delphine Collin, Ph.D., as Vice President, Biomolecular Sciences

CAMBRIDGE, Mass. May 14, 2019Cedilla Therapeutics today announced the appointment of Delphine Collin, Ph.D., as vice president, biomolecular sciences. In this role, she will advance Cedilla’s work to develop and leverage the biophysical and biochemical understanding of ligand-induced stabilization and degradation of therapeutically relevant protein targets.

“Delphine is an accomplished leader with a proven track record of developing successful discovery strategies and advancing preclinical projects,” said Brian Jones, Ph.D., Cedilla’s chief scientific officer. “Her deep expertise in protein characterization and protein-small molecule interactions will be invaluable as we explore promising new tools to modulate protein stability.”

Collin most recently served as chief innovation officer of HarkerBIO, a contract research organization focused on the structural enablement of early discovery research. Previously, she served as senior principal scientist at Boehringer Ingelheim (BI) and led a biophysics group focused on lead identification and optimization in the small molecule drug discovery group. While at BI, Collin also started her own consulting firm, Delphine Collin Consulting, LLC., where she supported companies with specialized biophysical approaches to drug discovery. Prior to BI, Collin was a research fellow at Merck & Co. Collin holds a Ph.D. in biophysical chemistry and doctorate in pharmaceutical sciences from the University of Paris XI, France.

“Cedilla is pursuing several exciting new avenues for protein degradation, and I’m delighted to join the team,” Collin said. “We’re committed to broadening the reach of small molecule therapeutics to address cancer and other diseases caused by protein dysregulation.”

About Cedilla Therapeutics

Cedilla Therapeutics is discovering and exploiting unique insights into protein stability. Cedilla’s integrated, multi-faceted approach has the potential to broaden the reach of small molecules by generating therapeutics that degrade protein targets as their primary mechanism of action. The approach harnesses intrinsic degradation pathways that are upstream of ubiquitination. Cedilla is focused on destabilizing oncoprotein targets using a product engine that is also applicable to targets outside of oncology. Cedilla was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass.

For more information, please visit www.cedillatx.com or follow us on LinkedIn.

Media Contact:

Stephanie Simon
Ten Bridge Communications
stephanie@tenbridgecommunications.com
617-581-9333

Cedilla Therapeutics Appoints Rosana Kapeller to Board of Directors

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Cedilla Therapeutics Appoints Rosana Kapeller to Board of Directors

CAMBRIDGE, Mass., July 10, 2018 – Cedilla Therapeutics today announced the appointment of veteran biopharma executive Rosana Kapeller, M.D., Ph.D., as an independent member of the board of directors. Kapeller, the former chief scientific officer at Nimbus Therapeutics, brings a wealth of experience in drug discovery, platform validation and corporate leadership.

“Rosana’s experience launching a successful biotech startup, building a robust drug discovery pipeline and ensuring sound corporate governance will be invaluable to us as we advance our mission to broaden the reach of small molecule therapeutics by harnessing protein stability mechanisms,” said Alexandra Glucksmann, Cedilla’s president and chief executive officer. “She is widely recognized as an exceptional leader and we are greatly looking forward to working with her.”

Kapeller spent more than eight years at Nimbus Therapeutics, leading the company’s drive to apply advanced computational technologies to the design and development of novel therapeutics. As Nimbus’s founding CSO, she assembled a strong scientific team that validated the company’s platform and advanced multiple promising programs. Before joining Nimbus, Kapeller served as founding vice president of research at Aileron Therapeutics. She started her career as a scientist at Millennium Pharmaceuticals, where she advanced through positions of increasing responsibility to director. Kapeller is an adviser to Atlas Ventures and has served as a consultant to Third Rock Ventures. She holds a Ph.D. in molecular and cellular physiology from Tufts University and a M.D. from Universidade do Estado do Rio de Janeiro in Brazil.

“Cedilla is pioneering new ways to leverage the cell’s intrinsic protein stability mechanisms for drug development,” Kapeller said. “I’m thrilled to join the board at this exciting time.”

About Cedilla Therapeutics

Cedilla Therapeutics is discovering and exploiting unique insights into protein stability. Cedilla’s integrated, multi-faceted approach has the potential to broaden the reach of small molecules by generating therapeutics that degrade protein targets as their primary mechanism of action. The approach harnesses intrinsic degradation pathways that are upstream of ubiquitination. Cedilla is focused on destabilizing oncoprotein targets using a product engine that is also applicable to targets outside of oncology. Cedilla was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass. For more information, please visit www.cedillatx.com.

Media Contact:

Stephanie Simon
Ten Bridge Communications
stephanie@tenbridgecommunications.com
617-581-9333

Cedilla Therapeutics Expands Leadership Team with New Appointments to Direct Biology, Drug Discovery and Proteomics

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Cedilla Therapeutics Expands Leadership Team with New Appointments to Direct Biology, Drug Discovery and Proteomics

CAMBRIDGE, Mass. June 28, 2018 – Cedilla Therapeutics today formally announced the appointment of three vice presidents with extensive experience in drug discovery to advance the company’s mission of harnessing existing protein stability mechanisms to redirect the course of disease.

Dale Porter, Ph.D., a veteran oncology researcher with experience from the Broad Institute and Novartis, has recently joined as vice president of biology. Iván Cornella-Taracido, Ph.D., former director of chemical biology at Merck Research Laboratories, joins Cedilla as vice president of proteomics and chemical biology. Eric Schwartz, Ph.D., former executive director of chemistry at Celgene, will be vice president of drug discovery.

“Dale, Iván and Eric are exceptional additions to the Cedilla team as we work to uncover the mechanisms that govern protein stability and apply those insights to drug development,” said Brian Jones, Ph.D., chief scientific officer at Cedilla. “Their complementary backgrounds in discovery and translational oncology, proteomics, chemical biology and medicinal chemistry, together with a combined 55 years of drug discovery experience, position us very nicely to succeed in developing novel treatments for cancer and other diseases by harnessing the endogenous mechanisms that underpin protein stability.”

Dale Porter, Ph.D. comes to Cedilla from the Broad Institute of MIT and Harvard, where he researched novel approaches for treating cancer. Most recently, he directed oncology drug discovery research in the William Sellers Lab, which is focused on the intersection of cancer biology and cancer genomics. Porter, who previously worked at Novartis, is co-author on more than 30 cancer research publications. He has a B.S. in biology and a Ph.D. in physiology from Cornell University and completed a postdoctoral fellowship in cancer genomics at the Dana-Farber Cancer Institute.

Iván Cornella-Taracido, Ph.D. joins Cedilla from Merck Research Laboratories, where he was the director of chemical biology. Prior to Merck, Cornella-Taracido held leadership positions at AstraZenca, where he established and managed the global chemical biology team; Sanofi, where he founded the company’s chemical genetics and proteomics team; and Novartis, where he was a founding member of the small molecule target identification and mode of action elucidation (TIDMoA) platform. Cornella-Taracido has a B.Sc. in chemistry, an M.Sc. in organic chemistry and a Ph.D. in organic chemistry from the Universidade da Coruña in Spain. He completed postdoctoral work at the Institute of Chemistry & Cell Biology of Harvard Medical School (now the Broad Institute of MIT and Harvard) and in the Boston College chemistry department.

Eric Schwartz, Ph.D. most recently served as executive director of chemistry at Celgene, where he led a covalent BTK inhibitor research program and helped establish a chemical biology group at the Cambridge site, while also serving as a core member of the executive team. Prior to Celgene, he held positions at Avila Therapeutics, Resolvyx Pharmaceuticals, Biogen Idec, UCB Research, Inc. and the Eisai Research Institute. Schwartz has a B.S. in chemistry from Ohio State University and a Ph.D. in organic chemistry from the University of Wisconsin-Madison. He also spent two years studying organic synthesis as a postdoctoral fellow at the University of Pittsburgh.

About Cedilla Therapeutics

Cedilla Therapeutics is discovering and exploiting unique insights into protein stability. Cedilla’s integrated, multi-faceted approach has the potential to broaden the reach of small molecules by generating therapeutics that degrade protein targets as their primary mechanism of action. The approach harnesses intrinsic degradation pathways that are upstream of ubiquitination. Cedilla is focused on destabilizing oncoprotein targets using a product engine that is also applicable to targets outside of oncology. Cedilla was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass. For more information, please visit www.cedillatx.com.

Media Contact:

Stephanie Simon
Ten Bridge Communications
stephanie@tenbridgecommunications.com
617-581-9333

Third Rock Ventures Launches Cedilla Therapeutics with $56 Million Investment to Target Protein Stability Using Small Molecule Therapeutics

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Third Rock Ventures Launches Cedilla Therapeutics with $56 Million Investment to Target Protein Stability Using Small Molecule Therapeutics

Company is targeting upstream aspects of native protein degradation pathways to develop new therapies for cancer

CAMBRIDGE, Mass., April 24, 2018 – Cedilla Therapeutics, a new biotechnology company broadening the reach of small molecule therapeutics by discovering and exploiting unique insights into protein stability, launched today with $56.2 million in Series A funding from Third Rock Ventures.

Cedilla is leveraging a growing understanding of the principles that dictate protein stability and applying those principles to target proteins that drive cancer and other diseases. Cedilla’s integrated product engine includes target-centric and unbiased approaches and is designed to produce small molecule therapeutics that degrade protein targets. Although degradation by small molecules has been observed serendipitously, degradation as a mechanism of action has not been pursued systematically in small molecule drug discovery.

Led by a veteran team with extensive drug discovery experience, Cedilla harnesses existing protein stability mechanisms that are upstream of ubiquitination and do not rely upon engineered recruitment of the cell’s degradation machinery.

“We are launching Cedilla at a time of rapidly growing insight into the mechanisms underlying protein stability,” said Alexandra Glucksmann, Ph.D., Cedilla’s president and chief executive officer. “We have designed a systematic approach to discover the rules that govern protein stability, which we will apply to find new points of therapeutic intervention. Our integrated product engine allows us to prosecute any protein of interest and to deliver precisely targeted therapeutics to patients in need.”

Cedilla’s small molecule drug discovery focuses on the transitions between stable and susceptible protein states to develop targeted therapies. Cedilla is building an integrated and multi-faceted product engine to enhance endogenous degradation pathways. Approaches include:

  • Direct ligand-induced degradation triggered by the binding of small molecules to target proteins
  • Identification and disruption of stabilizing protein-protein interactions
  • Discovery of upstream regulators that modulate the stability of target proteins
  • Implementation of large-scale proteomics to map protein susceptibility

“We are initially focused on oncology targets. We also believe our small molecule approach is broadly applicable, for example to access targets in the central nervous system,” said Brian Jones, Ph.D., Cedilla’s chief scientific officer.

The Cedilla management team includes recognized leaders in discovery chemistry, translational oncology research, molecular and cellular biology and company building. CEO Alexandra Glucksmann was a founding scientist at Millennium Pharmaceuticals and Cerulean Pharma and founding employee and chief operating officer at gene editing company Editas Medicine, Inc. Brian Jones, Cedilla’s chief scientific officer, has led the molecular discovery behind more than 20 investigational new drug (IND) applications across several therapeutic areas, and most recently served as head of discovery chemistry at Novartis Institutes for BioMedical Research in Cambridge. Other company leaders include Andres Tellez, Ph.D., senior director of business and strategy; and Dale Porter, Ph.D., vice president and head of biology.

Cedilla’s scientific founders are distinguished academics recognized for expertise in regulation of protein stability, cancer biology, proteomics and protein structure and dynamics. They include:

  • Alan D’Andrea, M.D., a professor at Harvard Medical School and director of the Center for DNA Damage and Repair at Dana-Faber Cancer Institute
  • Steve Gygi, Ph.D., a professor of cell biology at Harvard Medical School
  • Matthew Jacobson, Ph.D., a professor at the University of California, San Francisco School of Pharmacy
  • William Kaelin, Jr., M.D., a professor at the Dana-Farber Cancer Institute and Harvard Medical School and investigator of the Howard Hughes Medical Institute
  • Jack Taunton, Ph.D., a professor at the University of California, San Francisco School of Medicine

About Cedilla Therapeutics

Cedilla Therapeutics is discovering and exploiting unique insights into protein stability. Cedilla’s integrated, multi-faceted approach has the potential to broaden the reach of small molecules by generating therapeutics that degrade protein targets as their primary mechanism of action. The approach harnesses intrinsic degradation pathways that are upstream of ubiquitination. Cedilla is focused on destabilizing oncoprotein targets using a product engine that is also applicable to targets outside of oncology. Cedilla was launched in 2018 by Third Rock Ventures and is based in Cambridge, Mass. For more information, please visit www.cedillatx.com.

About Third Rock Ventures

Third Rock Ventures is a leading health care venture firm focused on disruptive areas of science and medicine to discover, launch and build companies that make a dramatic difference in people’s lives. By combining the team’s scientific vision, strategic leadership, operational expertise and innovative deal-making capabilities, Third Rock Ventures nurtures bold ideas that translate into successful business enterprises. Recognizing that the best way to create value for investors is to create value for patients, Third Rock companies are built on a solid foundation of science, medicine, people and business strategy. For more information, please visit www.thirdrockventures.com.

Media Contact:

Stephanie Simon
Ten Bridge Communications
stephanie@tenbridgecommunications.com
617-581-9333