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Senior Scientist, Structural Biology

Job description

We are looking for a Structural Biologist to join our team; we are looking for YOU!

 We are an energetic new company focused on harnessing intrinsic protein stability mechanisms to broaden the reach of small molecule therapeutics. By working on cancer and other diseases caused by protein dysregulation, in ways that are distinct from other approaches, we have an opportunity to create unique and valuable new medicines.

You are a collaborative and enthusiastic structural biologist, who is excited to build and drive drug discovery programs in a creative and purposeful environment. As a key contributor in our Biomolecular Sciences team, you will provide leadership and expertise in the structural characterization of novel drug targets by integrating your broad understanding of x-ray crystallography with protein dynamics, enzymology and biophysics.

We view you as an important scientist in the company, whose contributions will be critical to the success of our endeavor. Those contributions would include:

  • Working closely with teammates in Biomolecular Sciences leveraging a broad range of biochemical and biophysics techniques to understand protein dynamics and structure
  • Managing external structural biology collaborations (CROs)
  • Crystallizing, performing X-ray structure determination, and analyzing of important drug targets through working with external collaborators
  • Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols
  • Collaborating with multi-disciplinary teams including biology, chemical biology, proteomics and chemistry to develop a structural biology strategy
  • Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with chemistry group
  • Analyzing, documenting and reporting data clearly and concisely to project teams
  • Interacting with, and ensuring productivity of, collaborators and CROs

Some of the highlights of your background are:

  • Demonstrated ability to solve difficult problems in protein crystallography, structural biology and biophysics
  • Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts
  • Experience with other structural techniques (e.g. room temperature crystallography, electron microscopy, small-angle X-ray scattering) is preferred
  • Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience
  • An energizing individual as well as creative, flexible and rigorous scientist
  • Strong knowledge of the drug discovery process, with industry experience in implementing hit identification strategies through candidate selection
  • Proven experience in advancing programs to the clinic in a pharmaceutical/biotechnology setting;
  • Understanding of modeling and molecular dynamics favorably considered
  • A degree in a relevant subject and experience in the development and execution of biochemical assays in a biotech/pharma setting (for example, BS/MS in Biochemistry with 7-10 years of experience; Ph.D. with 3-5 years of experience)

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